Researchers at the Washington University School of Medicine in St. Louis recently found that a connection between serotonin and depression, long taken as gospel, does not actually exist. The research disproved a landmark 2003 study, which has since been cited more than 4,000 times, that linked the serotonin gene to inhibited ability to deal with stress and, in turn, a greater likelihood of depression.

By analyzing information from more than 40,000 people in more than 100 studies that have been done since 2003, the researchers found that the gene likely does not alter the impact stress has on depression.

The results, published last week in the journal Molecular Psychology, put an end to the two-decade-long debate about stress and serotonin genes.

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