Drugmaker Johnson & Johnson is set to face trial in a multibillion-dollar lawsuit by the state of Oklahoma aimed at pinning the blame for the opioid epidemic on its painkiller marketing.

Lawyers for the state and J&J are scheduled to appear on Tuesday in a state court in Norman, Oklahoma, to deliver their opening statements at the start of the first trial to result from more than 2,000 similar lawsuits against opioid manufacturers nationally.

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The lawsuits by state and local governments seek to hold the J&J and other companies responsible for a drug abuse epidemic that the U.S. Centers for Disease Control and Prevention says led to a record 47,600 opioid-related overdose deaths in 2017.

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